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Journal: BMJ Open
Article Title: Rationale and study design of the MINERVA study: Multicentre Investigation of Novel Electrocardiogram Risk markers in Ventricular Arrhythmia prediction—UK multicentre collaboration
doi: 10.1136/bmjopen-2021-059527
Figure Lengend Snippet: Derivation of Regional Restitution Instability Index (R2I2) and Peak ECG Restitution Slope (PERS). (A) Stimulation protocol demonstrating the fiducial points of T peak Q and QT peak (blue) which are required to plot on the restitution curve (B) gradients are fitted for each 40 ms overlapping least square linear segment. The mean of the SD of gradient differences from the mean gradient is taken as the R2I2. The mean of the peak restitution curve slope is calculated to be the PERS value (reproduced with permission from Nicolson 2014).
Article Snippet: Recording of the digital 12-lead ECG during the EP study protocol will be performed using a
Techniques: